GB2501219A — Orally bioavailable peptide drug compositions and methods thereof

USPTO Abstract

The present invention provides orally bioavailable peptide drug compositions including a cyclic peptide and an orally compatible absorption enhancer, as well as methods for providing increased oral bioavailability of peptide drugs. The oral composition includes a cyclic peptide; and at least one alkylsaccharide absorption enhancer. In another aspect, the present invention provides a method of increasing the oral bioavailability of a linear peptide. The method includes cyclizing a linear peptide to form a cyclic peptide; and orally administering the cyclized peptide in the presence of at least one alkylsaccharide absorption enhancer to a subject. In some embodiments, the cyclic peptide and the at least one alkylsaccharide are admixed to form a composition prior to oral administration.