GB2469792A — Oil-based pharmaceutical formulation for sublingual delivery

USPTO Abstract

A pharmaceutical composition for sublingual delivery comprises a neutral oil and a medicament soluble in said oil; providing that the medicament is not nitroglycerine. Preferred medicaments are nicotine; artemether; buprenorphine, fentanyl and other opioids. Preferred neutral oils are triglycerides from the Miglyol (RTM) range. Possible alternatives include maize oil, castor oil, olive oil, rapeseed oil, glycerol mono-oleates, linoleyl macrogolglycerides, oleoyl macrogolglycerides, vegetable fatty oils, medium chain triglycerides, coconut oil, fractioned palm kernel oil, hydrogenated cottonseed oil, omega-3-marine triglycerides, fish or cod liver oil, diglycerides, monoglycerides or diglycerol. The composition may be alcohol-free or alternatively include a co-solvent such as ethanol, isopropanol, propylene glycol or polypropylene glycol. It may incorporate flavourings (e.g. orange, clove, lemon, peppermint, menthol essential oils), preservatives (e.g. propyl or butyl parabens) and/or antioxidants (e.g. butylated hydroxy toluene, butylated hydroxy anisole, alpha tocopherol). Also disclosed is a delivery device adapted to deliver doses of the composition.