GB2463452A — Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof

USPTO Abstract

Pharmaceutical compositions comprising a compound of the formula (1):or a pharmaceutically acceptable salt or tautomer thereof and a pharmaceutically acceptable carrier and compounds of formula (1) per se or pharmaceutically acceptable salts or tautomers thereof, excluding certain isomers. R1and R2are each hydrogen or methyl, provided at least one of R1and R2is hydrogen, and X is CHOH or C=O. The compounds are 1,3,4,6,7,11b-hexahydrobenzo(a)quinolizine compounds, more specifically desmethyl derivatives of tetrabenazine, and may be useful in treating various diseases, in particular movement disorders such as Huntington's disease or Tourette's syndrome, depression, inflammatory disease, asthma, multiple sclerosis or an autoimmune myelitis, psychoses, cognitive deficit, schizophrenia, anxiety, dementia or diabetes mellitus.