GB2463451A — 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia

USPTO Abstract

3, 11b cis-dihydrotetrabenazine or pharmaceutically acceptable salt thereof for use in the treatment of dementia, wherein the 3, 11b cis-dihydrotetrabenazine is preferably of formula (I). The dementia may be a form selected from Alzheimer's disease, Lewy body dementia or vascular dementia wherein the dementia may arise from or be associated with (i) the accumulation of amyloid plaques in the brain; (ii) the development of neurofibrillary tangles in the brain; (iii) the accumulation of Lewy bodies in the brain ; (iv) the accumulation of cerebrovascular injury in the brain (v) an amyloidopathy; (vi) a taupathy (vii) a synucleinopathy; and/or a prionopathy. A 3, 11b cis-dihydrotetrabenazine or a pharmaceutically acceptable salt thereof, for use in treating a cognitive deficit associated with dementia is also outlined. Methods for the synthesis and pharmaceutical compositions comprising 3, 11b cis-dihydrotetrabenazine are also provided.