GB2444904A — A process for the preparation of an orally administered unit dose tablet

USPTO Abstract

The present invention is directed to a process for preparing an orally administered unit dose tablet comprising bisoprolol fumarate. The process comprises providing bisoprolol fumarate in a range of 1 to 20% by weight and a binding agent in a range of 65 to 95% by weight, in a range of bisoprolol fumarate : binding agent of 1:10 to 1:50; wherein at least 99% by weight of the bisoprolol fumarate particles are less than 220 microns in diameter, at least 90% by weight of the bisoprolol fumarate particles are less than 100 microns in diameter and at least 50% by weight of the bisoprolol fumarate particles are less than 30 microns in diameter, and at least 90% of the binding agent particles are less than 140 microns in diameter. The binding agent may be silicified microcrystalline cellulose and there may be a disintegrating agent comprising croscarmellose sodium or sodium starch glycolate. The ingredients may be sieved, blended, loaded into a tableting press compression machine, discharged and packaged.