GB2437488A — Pharmaceutical oily formulation for nasal or buccal administration

USPTO Abstract

A formulation for administration to a nasal or buccal cavity of a subject which comprises a non-aqueous liquid environment, preferably an emollient oil base, and at least one active molecule, preferably a dopamine agonist and especially apomorphine, in solution or suspension therein, wherein in one embodiment the formulation has such a viscosity as to be delivered as a liquid jet from a spray pump which is capable of delivering an aerosol spray of an aqueous formulation. The delivery device may be able to achieve a bidirectional air flow through the nasal airway of the subject, thereby securing velum closure. The active molecule may be degradable in aqueous solution either by oxidation or hydrolysis.