GB2422829A — Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor

USPTO Abstract

Compounds of formula (Ia) or (Ib): <EMI ID=1.1 HE=52 WI=107 LX=559 LY=799 TI=CF> <PC>wherein R<1>, R<2> and R<3> are independently hydrogen, halo, -C1-C6 alkyl, -O(C1-C6 alkyl), -C1-C6 alkyl(C3-C7 cycloalkyl), -CON(R<8>)2, -SOR<8>, -SO2R<8,> -SO2N(R<8>)2, -N(R<8>)2, -NR<8>COR<8>, -CO2R<8>, COR<8>, -SR<8>, -OH, -NO2 or -CN; ```each R<8> is independently hydrogen or C1-C6 alkyl; R<4> and R<5> are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R<6> is hydrogen or C1-C6 alkyl; R<7> is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or an aromatic moiety, any of which may optionally be substituted with one or more substituents selected from halo, C1-C6 alkyl, -O(C1-C6)alkyl, -R<10>, -OR<10>, C(R<10>)2 -CON(R<10>)2, -SOR<10> -SO2R<10>, - SO2N(R<10>)2, -N(R<10>)2, -NR<10>COR<10>, -CO2R<10>, -COR<10>, -SR<10>, -OH, -NO2 or -CN; ```wherein each R<10> is independently hydrogen, C1-C6 alkyl, aryl or substituted aryl; X is -S- or -SO2-; or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.