GB2395900A — Therapeutic composition for respiratory delivery

USPTO Abstract

A therapeutic composition in solid dose form comprising a mixture of first amorphous or non-crystalline microparticles comprising a bioactive agent and second amorphous non-crystalline microparticles comprising the same or a different bioactive agent, wherein the first microparticles are from 0.1 to 10žm in diameter and the secondmicroparticles are from 10 to 100 žm. Thus the microparticles are delivered via the nasal route to provide deep lung penetration (smaller microparticles) and deposition in the nasal cavity (larger microparticles). The bioactive agent may be an immunogen, particularly attenuated bacteria or virus, or an immunogenic peptide/protein. The glassy microparticles may be formed of hydrophobic derivatised carbohydrate (HDC). The therapeutic composition of the invention may be delivered by a nasal insufflator.