GB2299581A — 3-(Tetrahydropyridin-1-yl-methyl)pyrrolo[2,3-b]pyridine derivatives as ligands for dopamine receptor subtypes

USPTO Abstract

Compounds of formula I, or a salt or prodrug thereof: [wherein ```A represents hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halogen, cyano or trifluoromethyl; ```R 1 represents hydrogen, halogen, cyano, nitro, trifluoromethyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, C 1-6 alkyl, C 1-6 alkoxy, aryl(C 1-6 )alkoxy or C 2-6 alkylcarbonyl; ```Y represents a divalent monocyclic radical selected from the following groups of formula Ya to Yg: in which X represents oxygen, sulphur or N-R 3 ; Z represents CH or N; R and R 3 independently represent hydrogen or C 1-6 alkyl; and R 2 represents an optionally substituted aryl or heteroaryl group] constitute a class of pyrrolo[2,3-b]pyridine derivatives (linked via the 3-position thereof by a methylene group to a tetrahydropyridinyl moiety, the latter moiety being substituted in turn by an aryl- or heteroaryl-substituted divalent monocyclic radical) which are ligands for dopamine receptor subtypes within the body, in particular the D 4 subtype, and are accordingly of use in the treatment and/or prevention of disorders of the dopamine system, including schizophrenia and depression.