GB2290790A — Asymmetric synthesis of 6-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
Assigned to Merck and Co Inc · Expires 1996-01-10 · 30y expired
What this patent protects
An asymmetric synthesis of tetrahydronaphthalene analogues of formula <IMAGE> (where R4 is halogen, hydroxy or cyano) comprises, in order, the steps of a) mesylating an alcohol of the formula <IMAGE> b) converting the mesylate to the azide; and c) reduci…
USPTO Abstract
An asymmetric synthesis of tetrahydronaphthalene analogues of formula <IMAGE> (where R4 is halogen, hydroxy or cyano) comprises, in order, the steps of a) mesylating an alcohol of the formula <IMAGE> b) converting the mesylate to the azide; and c) reducing the azide. Such amines are important intermediates in the production of antiarrhythmic agents.
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