GB2227743A — Cyclohexanol derivatives

USPTO Abstract

Compounds having the formula I <IMAGE> where R<1> is -CN, -CO-N(CH3)2 or -CS-N(CH3)2 and R<2> is hydrogen, methyl or a removable protecting group are prepared by condensing a compound having the formula <IMAGE> where M is lithium, sodium, potassium or halomagnesium and R<3> is methyl or a removable protecting group, with cyclohexanone in a solvent comprising 80-100% of one or more hydrocarbons and 0-20% of one or more ethers. The solvent enables less inconvenient reaction temperatures to be used and higher yields to be obtained. Compounds (I) are new per se where R<1> is -CS-N(CH3)2. Compounds (I) are chemical intermediates for preparing N, N-dimethyl-2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl or 4-methoxyphenyl) ethylamine and pharmaceutically acceptable salts thereof. These end products are antidepressants.