GB2218983A — Spiro-substituted glutaramides as diuretics

USPTO Abstract

Compounds of the formula: <IMAGE> wherein A completes a 4 to 7 membered carbocyclic ring which may be saturated or mono-unsaturated and which may optionally be fused to a further saturated or unsaturated 5 or 6 membered carbocyclic ring; x is a bridged cyclic group of the formula:- <IMAGE> wherein Y is O, CH2 or (CH2)2, or a bicyclic group of the formula:- <IMAGE> wherein each of n and m is independently 1 or 2 and q is an integer of from 3 to 5; each of R and R<4> is independently H, C1-C6 alkyl, benzyl or an alternative biolabile ester-forming group; R<1> is H or C1-C4 alkyl; R<2> and R<3> are each independently H, OH, C1-C4 alkyl or C1-C4 alkoxy; and R<5> is a substituent; and pharmaceutically acceptable salts thereof and bioprecursors therefor. The compounds are diuretic agents having utility in the treatment of cardiovascular disorders such as hypertension and heart failure.