GB2090605A — Polymer of diallyl ammonium monomers pharmaceutical compositions thereof

USPTO Abstract

Polymers containing 55 to 90% of units of the formula (A) :wherein R<sup>1</sup> is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; and 10 to 45% of units of the formula (B) and (C):wherein R<sup>2</sup> is a hydrogen group of 5 to 19 carbon atoms, for example n-C<sub>11</sub>H<sub>23</sub>, R<sup>3</sup> is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, R<sup>4</sup> is a hydrocarbon group of 5 to 19 carbon atoms, for example n-C<sub>11</sub>H<sub>23</sub> and X<sup>-</sup> is an anion and which contain at least 10% of units of formula (C) and are free from polymeric species having a molecular weight of less than 10,000 are described. The polymers possess antimicrobial activity against common pathogens. Isotonic aqueous solutions containing 0.002 to <sub>0</sub>.<sub>0</sub>25% of the polymer are suitable for the sterilisation of contact lenses for example by immersion of the lens in the solution overnight. Hydrophilic ointments containing from 0.002 to 0.25% of the polymer are suitable for the treatment of bacterial infection of lesions of the skin such as burns and ulcers.