GB2023594A — 1-substituted alkyl-4-(3- trifluoromethylthiophenyl)- piperazines

USPTO Abstract

Compounds having the general formula (I> <IMAGE> in which n is 1, 2 or 3 and R represents (i) a group of formula: <IMAGE> (A) in which R1 and R2 represent hydrogen atoms or together represent a group of formula: <IMAGE> thereby completing a benzene ring fused to the heterocyclic ring shown in formula (A), X is a -S-, -O-, imino, alkyl-imino or methylene group and m is 0 or 1 or R represents (ii) a group of formula: <IMAGE> (B), (iii) a 2-tetrahydrofuryl group, (iv) a group of formula -CH2-S-Z, Z representing a hydrogen atom, alkyl group or -CO- alkyl group or (v) a group of formula -CH2-O- alkyl, having from 1 to 8 carbon atoms, and their pharmaceutically acceptable acid addition salts are useful in therapy, especially for treatment of anxiety and depression.