GB1489711A — 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the

USPTO Abstract

1489711 1 - (Phenoxyphenyl)piperazines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 21 July 1976 [21 July 1975] 30392/75 Heading C2C 1 - (Phenoxyphenyl)piperazines of general formula wherein R and R<SP>1</SP>, same or different, are each H, halogen, C 1-5 alkyl, alkoxy or alkylthio, nitro, amino, CF 3 , CF 3 S-, CF 3 O-, (C 1-5 alkoxy)carbonyl or -SO 2 N(CH 3 ) 2 , are prepared by reacting a compound with a bis - (# - haloethyl)amine of general formula NH(CH 2 CH 2 X) 2 , in which X is halogen, and basifying the resulting hydrohalide. Amongst numerous examples the compounds 1 - (3 - phenoxyphenyl)piperazine, 1 - [4 - (4- methoxyphenoxy)phenyl]piperazine and 1- (3 - dimethylsulphamoyl - 4 - phenoxyphenyl) piperazine are prepared. Pharmaceutical compositions comprise as active ingredient a compound of Formula I or a physiologically tolerable acid addition salt thereof, in admixture with a pharmaceutically suitable carrier.