GB1390772A — Oral narcotic composition

USPTO Abstract

1390772 Narcotic compositions ENDO LABORATORIES INC 10 March 1972 [7 May 1971] 11319/72 Heading A5B Pharmaceutical compositions comprise: (a) a compound, having substantial narcotic activity both orally and by injection, selected from oxycodone, hydrocodone, codeine, propoxyphene and pentazocine, and salts thereof and, (b) a narcotic antagonist which is substantially less active orally than by injection selected from: (i) naloxone and its pharmaceutically acceptable salts, (ii) N-cyclopropylmethyl-7, 8-dihydro-14-hydroxynormophinone and its salts and, (iii) 21-cyclopropyl-7#-(1- hydroxy-1-methylethyl)-6, 14-endo-ethano-tetrahydrooripavine and its salts, the weight ratio of (a) to (b) being within certain ranges according to the individual compounds used so that substance (b) does not block the narcotic effect of (a) when the composition is administered orally, but does prevent an acute euphoriant effect by (a) when the composition is injected. Other active substances may also be present, e.g. aspirin, phenacetin, caffeine, antihistamines and antispasmodics.