GB1368948A — Pyridine derivatives

USPTO Abstract

1368948 Pyridine derivatives MANUFACTURE DE PRODUITS PHARMACEUTIQUES A CHRISTIAENS SA 2 Nov 1971 [11 Nov 1970] 53675/70 Heading C2C Novel compounds (I), (II) and (III) (including salts thereof) wherein R 1 in the 3- or 5-position of the pyridine nucleus represents a sulphonic acid group, the esters and salts thereof, a primary, secondary or tertiary sulphonamido including acylated sulphonamido group, a group of the formula in which R 3 and R 4 form together with the nitrogen atom to which they are attached a heterocyclic ring which may contain another hetero-atom and may be substituted, when R 2 in the 2- or 4-position of the pyridine nucleus represents an anilino group which is substituted; or R 1 in the 3- or 5-position, in addition to the previous meanings may also represent a cyano or a carboxy group, the esters and salts thereof, a primary, secondary or tertiary carboxamido group when R 2 in the 2- or 4- position represents a piperazinyl group which may be substituted; R 5 and R 7 represent each an alkyl group and R 6 represents hydrogen, or an alkyl or aryl group which may be substituted, are made according to standard methods; novel compounds (VI) are used as starting materials and (II) and (III) are obtained by cyclization (X is halogen). Sulphochlorides related to (I) are prepared as intermediates. Pharmaceutical preparations having antiinflammatory and anti-pyretic properties contain (I), (II) and/or (III) as active ingredient. Administration may be orally, rectally, parenterally or topically.