GB1340032A — Biologically active ketones

USPTO Abstract

1340032 m - Halo - α - t - butylaminopropiophenones WELLCOME FOUNDATION Ltd (Burroughs Wellcome & Co (USA) Inc) 3 Dec 1970 [4 Dec 1969] 59231/69 Heading C2C Novel compounds of Formula I and acid addition salts thereof wherein X is Cl or F are prepared by one of the following methods: (a) a compound of Formula Va wherein Hal is Cl, Br or I is reacted with t-butyl amine; (b) a compound of formula is oxidized or (c) a compound of formula wherein R<SP>1</SP> is C 1-3 alkoxy is reacted with t-butylamine and in all eases optionally followed by salt formation. Intermediates of Formula Va above are prepared by halogenation of the ketones of formula obtained by reaction of the appropriate halophenylnitrile with ethyl magnesium bromide followed by acidification. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having antidepressant activity comprise an above novel compound and a carrier or diluent. Treatment of depression in non- human animals comprises administration of the above novel compounds or compositions.