GB1158283A — Composition to be Applied to Skin and Process for Preparing Same.

USPTO Abstract

1,158,283. Compositions for topical application. FOSTER-MILBURN CO. 5 Oct., 1966 [21 Oct., 1965], No. 44558/66. Heading A5B. Compositions to be applied to the skin and having increased percutaneous absorption through and retention in skin comprise a stable, topically active chemical compound (e.g. an anti-acne agent, an anti-inflammatory agent, an anticholinergic, an emollient, a sex hormone, crude coal tar, an antipsoriatic agent or an antimetabolite) solubilized in a pharmaceutically acceptable vehicle having as one component an amide having the structural formula wherein R<SP>1</SP> is H or Me, R<SP>2</SP> is H or an alkyl radical containing not more than 2 carbon atoms, and R<SP>3</SP> is an alkyl radical containing not more than 2 carbon atoms. The amide is preferably N,N-dimethyl acetamide, N,N- dimethyl formamide or N,N-diethyl acetamide. The topically active chemical compound may be an anti-inflammatory agent, e.g. triamcinolone acetonide, fluocinolone acetonide, betamethasone valerate, flurandren alone acetonide and hydrocortisone, an anticholinergic e.g. hexopyrronium bromide, an antimetabolite e.g. 5-fluorouracil, 4-amino-n<SP>10</SP>-methylpteroylglutamic acid and b-mercaptopurine; an antimicrobial agent e.g. erythromycin, tetracyclines, chloromycetin, oleandomycin, chloramphenicol, 2,2'-methylenebis (3,4,6-trichlorophenol), 3,4',5-tribromosalicylanilide, 3,4,4'- trichlorocarbanilide, nystatin, undecylenic acid, sulphur, salicylic acid, parachlorometaxylenol, 2-(4'-thiazolyl)-benzimidazole, iodine, iodochlorhydroxyguin- and 5-iodo-2'-deoxyuridine, an emollient e.g. lanolin and lanolin alcohols and their ethoxylated and/or acetylated products, glycerol, glycols and their derivatives, fatty acids, their esters, alcohols and derivatives; a sex hormone e.g. testosterone and oestradial; a sunscreen agent e.g. para-aminobenzoic acid, amyl p-dimethylaminobenzoate, cinnamic acid and benzophenones and their derivatives and coal tar products including anthracene and a composition containing sulphur, salicylic acid, hexachlorophene and crude coal tar extract. The amides may be used alone or in combination with other additional pharmaceutically acceptable surface active agents, emulsifiers, solvents, vehicles or other pharmaceutically acceptable bases.