GB0206860D0 — Compounds

USPTO Abstract

A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X<SUB>1 </SUB>is N or CR<SUB>3</SUB>; X<SUB>2 </SUB>is N or CR<SUB>4</SUB>; X<SUB>3 </SUB>is N or CR<SUB>5</SUB>; X<SUB>4 </SUB>is N or CR<SUB>6</SUB>. with the proviso that at least one but not more than two of X<SUB>1</SUB>, X<SUB>2</SUB>, X<SUB>3 </SUB>and X<SUB>4 </SUB>represents N. R<SUB>1 </SUB>is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X<SUB>5 </SUB>is a group selected from N or CR<SUB>7 </SUB>and X<SUB>6 </SUB>is a group selected from O, S or NR<SUB>8</SUB>; X<SUB>7 </SUB>and X<SUB>8 </SUB>which may be the same or different is a group selected from N or CR<SUB>9</SUB>; X<SUB>9 </SUB>is a group selected from O, S or NR<SUB>8 </SUB>and X<SUB>10 </SUB>is N or CR<SUB>10</SUB>; X<SUB>11</SUB>, X<SUB>12 </SUB>and X<SUB>13 </SUB>may be the same or different and selected from a group N or CR<SUB>11</SUB>; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.