EP4719360A1 — Solid elacestrant dihydrochloride compositions, methods of making the same, and methods of treatment using the same

USPTO Abstract

Solid pharmaceutical compositions of elacestrant dihydrochloride with high hardness values increase the dissolution time for elacestrant. Methods of making solid pharmaceutical elacestrant dihydrochloride compositions are disclosed, in which a mixture comprising elacestrant dihydrochloride and one or more pharmaceutically acceptable excipients is compressed at a pressure of at least 1 kN to produce a tablet with high hardness and a favorable dissolution profile. Methods of treatment for breast cancer include administering the solid pharmaceutical composition to a human subject.