EP4696303A1 — All natural granulate

USPTO Abstract

The present disclosure relates to a method of producing a granulate based on all-natural ingredients, a granulate obtainable by said method, and its use as a tableting excipient and for the production of other oral solid dosage forms such as capsules having excellent flow properties and excellent compressibility. The method includes the steps of introducing a carrier powder from a plant material into a high-shear mixer granulator, wherein the carrier material exhibits an angle of repose (AoR), as measured according to the fixed funnel method using a plastic funnel with a distance of 7 cm drop height to a 10 cm diameter disk, of at most 45°, preferably of at most 40°, such as between 30° and 45°, preferably between 35° and 40°; introducing a syrup - component (b) - into the mixer while mixing under high shear, where the organic syrup has a loss on drying (LoD) between 10 wt.% and 70 wt%, preferably between 15 wt.% and 30 wt.%, based on the total weight of the syrup; mixing the components in the high shear mixer to produce a granulate.