EP4523685A1 — Dihydroisoxazole compound for use in the treatment of ectoparasite infestations on fish

USPTO Abstract

Ectoparasite infestations in fish farming can pose significant challenges and issues for aquaculture operations. This disclosure generally relates to treatment or control of ectoparasite infestations (such as sea lice infestations) on fish (such as salmonids) using a particular dosing regimen of an isoxazoline. In particular, the dosing regimen includes oral administration of the active ingredient: (S)-3-methyl-N-(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide, including salts, or N-oxide, or solvates thereof, of structural formula at a dosage (i.e., in a dose) of from about 0.025 mg/kg/d to about 0.250 mg/kg/d, preferably at a dosage of from about 0.025 mg/kg/d to about 0.125 mg/kg/d. In particular, the dosing regimen can include oral administration from about 3 to about 10 consecutive days, preferably during 7 consecutive days.