EP4512483A3 — 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy

USPTO Abstract

A compound having formula (10) or a pharmaceutically acceptable salt thereof, wherein RI and R2 are independently selected from C 1-4 alkylphenyl, H, C 1-4 alkyl, C 1-4 alkylphenylketone, C 1-4 benzyl-piperazine, C 1-4 alkylthienyl, C 1-4 alkylpyridinyl, C -4 alkylisoxazolidinyl, C 1-4 alkylmorpholinyl, C 1-4 alkylthiazolyl, and C 1-4 alkylpyrazinyl, wherein the C 1-4 alkylphenyl, C 1-4 alkyl, C 1-4 alkylphenylketone, C 1-4 benzyl-piperazine, C 1-4 alkylthienyl, C 1-4 alkylpyridinyl, C 1-4 alkylisoxazolidinyl, C 1-4 alkylmorpholinyl, C 1-4 alkylthiazolyl, and C 1-4 alkylpyrazinyl are optionally substituted with halogen, C 1-4 alkyl, C 1-4 alkoxyl, hydroxyl, or perhalogenated C 1-4 alkyl, and wherein when R 1 represents CH 2 Ph, R 2 does not represent CH 2 -((2-CH 3 )-Ph). The compound can be used for treating cancer.