EP4458348A2 — Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof

USPTO Abstract

The present invention provides a pharmaceutical composition containing the following compound having antiviral action: P is hydrogen or a group to form a prodrug; A 1 is CR 1 A R 1 B , S or O; A 2 is CR 2 A R 2 B , S or O; A 3 is CR 3 A R 3 B , S or O; A 4 is each independently CR 4 A R 4 B , S or O; the number of hetero atoms among atoms constituting the ring which consists of A 1 , A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 4 , is 1 or 2; R 1 A and R 1 B are each independently hydrogen, halogen, alkyl, or the like; R 2 A and R 2 B are each independently hydrogen, halogen, alkyl, or the like; R 3 A and R 3 B are each independently hydrogen, halogen, alkyl, or the like; R 4 A and R 4 B are each independently hydrogen, halogen, alkyl, or the like; R 3 A and R 3 B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle; R 1 is fluorine; m is any integer of 1 to 2; and n is any integer of 1 to 2.