EP4340840A1 — Fgfr tyrosine kinase inhibitors for the treatment of advanced solid tumors

USPTO Abstract

Disclosed herein are methods of treating cancer, said methods comprising administering a therapeutically effective amount of erdafitinib to a patient who has been diagnosed with cancer and who harbors at least one fibroblast growth factor receptor (FGFR) fusion selected from FGFR2-CCDC102A, FGFR2-CCDC147, FGFR2-ENOX1, FGFR2-GPHN, FGFR2-LCN10, FGFR2-PDE3A, FGFR2-RANBP2, FGFR3-ENOX1, FGFR3-TMEM247, IGSF3-FGFR1, RHPN2-FGFR1, and RRM2B-FGFR2. Also disclosed herein are methods of treating cancer comprising: evaluating a biological sample from a patient who has been diagnosed with cancer and who harbors at least one FGFR gene alteration, wherein the cancer is cholangiocarcinoma, high-grade glioma, pancreatic cancer, squamous non-small-cell lung cancer (NSCLC), non-squamous NSCLC, breast cancer, colorectal cancer, endometrial cancer, gastric cancer, ovarian cancer, cancer of unknown primary, cervical cancer, squamous cell head and neck cancer, esophageal cancer, low-grade glioma, prostate cancer, salivary gland cancer, basal cell carcinoma, thymic cancer, small intestine adenocarcinoma, hepatocellular carcinoma, microcystic adnexal carcinoma, spinocellular carcinoma, gastrointestinal stromal tumor, or parathyroid carcinoma; and administering a therapeutically effective dose of an FGFR inhibitor to the patient if at least one FGFR gene alteration is present in the sample.