EP4262986A1 — Compounds useful as t cell activators

USPTO Abstract

Compounds are provided having structure (I): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, or isotope thereof, wherein X, L, Y, R1, R2, R3 and Cy are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided. Methods are provided wherein the compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) or are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. More specifically, methods of treating a proliferative or a viral infection are provided by administering to a subject in need thereof, an effective amount of the pharmaceutical composition containing compounds of structure (I).