EP4219508A1 — Substituted polycyclic pyridone derivative and prodrug thereof

USPTO Abstract

The present inventon provides the following compounds having anti-viral activity.A<sup>1</sup> is CR<sup>1A</sup>R<sup>1B</sup>, S or O;A<sup>2</sup> is CR<sup>2A</sup>R<sup>2B</sup>, S or O;A<sup>3</sup> is CR<sup>3A</sup>R<sup>3B</sup>, S or O;A<sup>4</sup> is CR<sup>4A</sup>R<sup>4B</sup>, S or O;the number of hetero atoms among atoms constituting the ring which consists of A<sup>1</sup>, A<sup>2</sup>, A<sup>3</sup>, A<sup>4</sup>, nitrogen atom adjacent to A<sup>1</sup> and carbon atom adjacent to A<sup>1</sup>, is 1 or 2;R<sup>1A</sup> and R<sup>1B</sup> are each independently hydrogen, halogen, alkyl, or the like;R<sup>2A</sup> and R<sup>2B</sup> are each independently hydrogen, halogen, alkyl, or the like;R<sup>3A</sup> and R<sup>3B</sup> are each independently hydrogen, halogen, alkyl, or the like;R<sup>4A</sup> and R<sup>4B</sup> are each independently hydrogen, halogen, alkyl, or the like;R<sup>3A</sup> and R<sup>3B</sup> may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle;X is CH<sub>2</sub>, S or O;R<sup>1</sup> is each independently halogen, hydroxy, or the like;m is any integer of 0 to 2; andn is any integer of 1 to 2.