EP4154904A1 — Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins

USPTO Abstract

Disclosed herein are methods for treating patients that may develop or already have preexisting gene therapy neutralizing antibodies by administering a protease that cleaves peptide bonds present in immunoglobulins or by administering a glycosidase that cleaves carbohydrate residues present on immunoglobulins, or other similar enzymatic cleavage of immunoglobulins in vivo. Also disclosed are methods for utilizing IdeS and other immunoglobulin G-degrading enzyme polypeptides for gene therapy treatment of a disease in a patient in need thereof.