EP3936113A1 — Hydrophilic degradable microsphere for delivering travoprost

USPTO Abstract

The invention relates to a composition comprising an effective amount of a prostaglandin analogue, at least one hydrophilic degradable microsphere comprising a crosslinked matrix, and a pharmaceutically acceptable carrier for administration by injection, the crosslinked matrix being based on at least a) between 10 % and 90 % of hydrophilic monomer of general formula (I); b) between 0.1 and 30% mol of a cyclic monomer having an exo-methylene group of formula (II); and c) between 5 % and 90 % of one degradable block copolymer cross-linker, wherein the degradable block copolymer crosslinker is linear or star-shaped and presents (CH<sub>2</sub>=(CR<sub>11</sub>))-groups at all its extremities. The invention also relates to such a composition for use for preventing and/or treating moderate to ocular hypertension or glaucoma.