EP3851142A1 — Nozzles for nasal drug delivery

USPTO Abstract

A nozzle for use in delivering an intranasal dosage form. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. A nozzle body defining a plurality of channels is provided. The channels are disposed along the longitudinal axis and are symmetric about a circle around the longitudinal axis, and the proximal end of each of the plurality of channels is configured to be in fluid communication with the drug product inlet such that the received mixture passes through each of the channels. An outlet orifice is disposed at the end of each channel such that the outlet orifices generate a plurality of streams of the mixture that form a plume once exited the outlet orifices, wherein an angle of the plume does not exceed 5 degrees.