EP3843735A1 — Selective presenilin-2 gamma-secretase inhibitors
Assigned to Universiteit Maastricht · Expires 2021-07-07 · 5y expired
What this patent protects
The present invention relates to selective presenilin-2 γ-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 γ-secretase inhibito…
USPTO Abstract
The present invention relates to selective presenilin-2 γ-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 γ-secretase inhibitors for use as a highly selective anti-cancer treatment. Preferred selective presenilin-2 γ-secretase inhibitors include small molecules, like 4- aminoquinolines or imidazole compounds, (monoclonal) antibodies and known γ-secretase inhibitors or analogues and combinations thereof.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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