EP3808363A1 — Therapeutic agents for reducing parathyroid hormone levels

USPTO Abstract

Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X<sub>1</sub> - X<sub>2</sub> - X<sub>3</sub> - X<sub>4</sub> - X<sub>5</sub> - X<sub>6</sub> - X<sub>7</sub>, wherein the X<sub>1</sub> subunit comprises a thiol-containing moiety and the distribution of charge on the X<sub>2</sub>-X<sub>7</sub> subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.