EP3805222A2 — 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one derivatives, salts thereof and their use in therapy

USPTO Abstract

A compound having formula (10)or a pharmaceutically acceptable salt thereof, wherein R<sub>1</sub> and R<sub>2</sub> are independently selected from C<sub>1-4</sub>alkylphenyl, H, C<sub>1-4</sub>alkyl, C<sub>1-4</sub>alkylphenylketone, C<sub>1-4</sub>benzyl-piperazine, C<sub>1-4</sub>alkylthienyl, C<sub>1-4</sub>alkylpyridinyl, C<sub>1-4</sub>alkylisoxazolidinyl, C<sub>1-4</sub>alkylmorpholinyl, C<sub>1-4</sub>alkylthiazolyl, and C<sub>1-4</sub>alkylpyrazinyl, wherein the C<sub>1-4</sub>alkylphenyl, C<sub>1-4</sub>alkyl, C<sub>1-4</sub>alkylphenylketone, C<sub>1-4</sub>benzyl-piperazine, C<sub>1-4</sub>alkylthienyl, C<sub>1-4</sub>alkylpyridinyl, C<sub>1-4</sub>alkylisoxazolidinyl, C<sub>1-4</sub>alkylmorpholinyl, C<sub>1-4</sub>alkylthiazolyl, and C<sub>1-4</sub>alkylpyrazinyl are optionally substituted with halogen, C<sub>1-4</sub>alkyl, C<sub>1-4</sub>alkoxyl, hydroxyl, or perhalogenated C<sub>1-4</sub>alkyl, and wherein when R<sub>1</sub> represents CH<sub>2</sub>Ph, R<sub>2</sub> does not represent CH<sub>2</sub>-((2-CH<sub>3</sub>)-Ph). The compound can be used for treating cancer.