EP3661503A1 — Antifungal agents with enhanced activity in acidic ph

USPTO Abstract

The triterpenoid antifungal compounds derived from enfumafungin are used to treat or prevent fungal infections occurring under or under acidic conditions, where the pH is less than about 7, because their efficacy is unexpectedly improved under such conditions. conditions. Triterpenoids derived from enfumafungin (or pharmaceutically acceptable salts or hydrates thereof) are inhibitors of (1,3) -β-D-glucan synthesis and are useful in the treatment or prevention of infections. yeast or filamentous fungi that develop in low pH anatomical areas, such as the vaginal cavity, or under acidic local environment conditions such as those observed in fungal abscesses, in empyema, or in infections of the upper gastrointestinal tract.