EP3645003A2 — Combination and uses and treatments thereof

USPTO Abstract

The present invention provides methods of treating or preventing human immunodeficiency virus 1 (HIV-1) or human immunodeficiency virus 2 (HIV-2) in a non-viremic patient in need thereof, including the patient of an antiretroviral regimen comprising at least three antiretroviral agents in a regimen comprising only two antiretroviral agents. In one aspect, the regimen is dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. According to another aspect of the invention, a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof is further described.