EP3632907A1 — N-(azaaryl)cyclolactam-1-carboxamide derivative, preparation method therefor, and use thereof

USPTO Abstract

An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the present invention. Each substituent being defined in the specification and claims. The series of compounds of the present invention can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasiscancer , and are expected to be developed into a new generation of CSF-1R inhibitor drugs.