EP3599237A1 — Pharmaceutical composition of the glucosylceramide synthase inhibitor eliglustat for the treatment gaucher's disease comprising adjusting the individual therapeutical dose to the p450 metabolism of the patient
Assigned to Genzyme Corp · Expires 2020-01-29 · 6y expired
What this patent protects
The present invention relates to a pharmaceutical composition comprising the hemitartrate salt of Eliglustat (Genz 112638; N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide) represented by the following structural formula:(Formula…
USPTO Abstract
The present invention relates to a pharmaceutical composition comprising the hemitartrate salt of Eliglustat (Genz 112638; N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide) represented by the following structural formula:(Formula I Hemitartrate)as an inhibitor of the glucosylceramide synthase (GCS) for use in a method of treating Fabry's or Gaucher's disease, the method comprising adjusting the individual therapeutical dose to the P450 metabolism of the patient.Particular single crystalline forms of Eliglustat Hemitartrate are characterized by a variety of properties and physical measurements as well as methods of producing crystalline Eliglustat Hemitartrate and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations 10 in subjects to treat Fabry's or Gaucher's disease, are also discussed.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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