EP3572070A1 — Local anesthesia pain-relieving and sustained-release drug delivery system, as well as preparation method therefor and use thereof
Assigned to Xi'an Libang Pharmaceutical Co ltd · Expires 2019-11-27 · 6y expired
What this patent protects
The present invention discloses a novel local anesthetic analgesic sustained-release drug delivery system, including an internal aqueous phase, an external aqueous phase, an oil phase, an organic solvent, an isoosmotic regulator and a pH regulator, wherein the internal aqueous ph…
USPTO Abstract
The present invention discloses a novel local anesthetic analgesic sustained-release drug delivery system, including an internal aqueous phase, an external aqueous phase, an oil phase, an organic solvent, an isoosmotic regulator and a pH regulator, wherein the internal aqueous phase includes an analgesic, a drug solvent and a drug solubilizer, wherein the analgesic is selected from one of bupivacaine, levobupivacaine, ropivacaine, lidocaine and tetracaine, and the analgesic is in a free base form or an acid saline form; the drug solvent is selected from inorganic acid containing N or P; and the drug solubilizer is selected from one or more of saccharide and ring-shaped organic acid. The multivesicular liposome prepared in the present invention has the advantages of high encapsulation percentage and drug loading capacity, uniform grain size, and good sustained-release effect.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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