EP3406600A1 — Trpm8 receptor agonist compounds and uses thereof

USPTO Abstract

The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C 1 -C 8 ) alkyl; b) optionally substituted (C 3 -C 6 ) cycloalkyl; c) optionally substituted (C 6 -C 14 ) aryl; d) optionally substituted (C 6 -C 14 ) heteroaryl; e) C(0)-(C 6 -C 14 ) aryl, in which group (C 6 -C 14 ) aryl is optionally substituted; f) C(0)-(C 6 -C 14 ) heteroaryl, in which group (C 6 -C 14 ) heteroaryl is optionally substituted; g) CH(OH)-(C 6 -C 14 ) aryl, in which group (C 6 -C 14 ) aryl is optionally substituted; and h) CH(OH)-(C 6 -C 14 ) heteroaryl, in which group (C 6 -C 14 ) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.