EP3284519A8 — Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity

USPTO Abstract

The present invention is to provide a novel compound (I-1) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. wherein A ring is substituted ring of (a), (b) or (c) wherein Z is O or NR 19 , R 19 is hydrogen, C 1-10 alkyl, C 2-8 alkenyl, C 1-10 alkylcarbonyl or C 1-10 alkylsulfonyl, and the other substituents on the A ring form a ring; R 14 and R X are hydrogen; a broken line represents the presence or absence of a bond, provided that when the broken line represents the presence of a bond, R X is not present; R 1 is hydrogen or C 1-10 alkyl; X is C 1-6 alkylene; R 2 is phenyl or phenyl substituted with at least halogen; R 3 is hydrogen, halogen, hydroxy, C 1-10 alkyl, C 2-8 alkenyl, C 1-10 alkoxy, C 2-8 alkenyloxy or amino; or a pharmaceutically acceptable salt, or solvate thereof.