EP Patent

EP3281939A1 — Method of producing stable crystal of 4-oxoquinoline compound

Assigned to Japan Tobacco Inc · Expires 2018-02-14 · 8y expired

What this patent protects

A method of producing a crystal (crystal form III) of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which has an X-ray powder diffraction pattern having characteristic diffraction peaks at diffraction an…

USPTO Abstract

A method of producing a crystal (crystal form III) of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which has an X-ray powder diffraction pattern having characteristic diffraction peaks at diffraction angels 2θ of 8.54°, 14.02°, 15.68°, 17.06°, 17.24°, 24.16°, 25.74° as measured by X-ray powder diffractometer, wherein the method comprises: dissolving a crystal (crystal form II) of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which has an X-ray powder diffraction pattern having characteristic diffraction peaks at diffraction angles 2θ of 6.56°, 13.20°, 19.86°, 20.84°, 21.22°, 25.22° as measured by X-ray powder diffractometer, in a solvent; and adding a seed crystal (crystal form III) of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which has an X-ray powder diffraction pattern having characteristic diffraction peaks at diffraction angles of 2θ of 8.54°, 14.02°, 15.68°, 17.06°, 17.24°, 24.16°, 25.74° as measured by X-ray powder diffractometer, to the solution.

Drugs covered by this patent

Patent Metadata

Patent number
EP3281939A1
Jurisdiction
EP
Classification
—
Expires
2018-02-14
Drug substance claim
No
Drug product claim
No
Assignee
Japan Tobacco Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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