EP3112334A1 — Process for manufacturing 1-cyclopropyl-naphthalenes
Assigned to Patheon Austria GmbH and Co KG · Expires 2017-01-04 · 9y expired
What this patent protects
A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula 1 wherein R 1 -R 7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethyl-ketone with a base and a first solvent …
USPTO Abstract
A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula 1 wherein R 1 -R 7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethyl-ketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethyl-ketone is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1 H -pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190°C to obtain the compound of Formula 1.
Drugs covered by this patent
- Aloprim (ALLOPURINOL) · Casper Pharma Llc
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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