EP2993171A1 — Method for the production of 18F-labeled PSMA-specific PET-tracers
Assigned to Max Planck Gesellschaft zur Foerderung der Wissenschaften eV · Expires 2016-03-09 · 10y expired
What this patent protects
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18 F - are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB pro…
USPTO Abstract
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18 F - are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [ 18 F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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