EP2635263A1 — A composition comprising s-[2-([[1-(2-ethylbutyl)-cyclohexyl]-carbonyl]amino)phenyl]2-methylpropanethioate and croscarmellose sodium

USPTO Abstract

The present invention relates to a composition comprising: a) S-[2-([[1-(2-ethylbutyl)-cyclohexyl]-carbonyl]amino)phenyl]2-methylpropanethioate, and b) croscarmellose sodium. The present invention also relates to a process for the preparation of a composition comprising the following steps: a) Mixing and granulating, S-[2-([[1-(2-ethylbutyl)-cyclohexyl]-carbonyl]amino)phenyl]2-methylpropanethioate, crospovidone micronized, microcrystalline cellulose, croscarmellose sodium and hydroxypropyl methylcellulose; b) Spraying up to 0.5% by weight of hydroxypropyl methylcellulose in water or in 10% - 30% ethanol by weight/70% - 90% water by weight, onto the granulates obtained according to step a); c) drying the granulates; and d) blending microcrystalline cellulose, colloidal silicon dioxide and sodium stearylfumarate with the dry granulates obtained according to step c).