EP Patent

EP2525223A1 — In vitro method for predicting in vivo genotoxicity of chemical compounds.

Assigned to Universiteit Maastricht · Expires 2012-11-21 · 13y expired

What this patent protects

The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. In particular, the invention provides a method for predicting the in vivo genotoxicity of a compound comprising the steps of performing an Ames tes…

USPTO Abstract

The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. In particular, the invention provides a method for predicting the in vivo genotoxicity of a compound comprising the steps of performing an Ames test on the compound and determining if the result is positive or negative, followed by a step wherein the gene expression of at least 3 genes is determined in a HepG2 cell, compared to a reference value and predicting that the compound is in vivo genotoxic if the expression level of more than 2 of the genes is above a reference value.

Drugs covered by this patent

Patent Metadata

Patent number
EP2525223A1
Jurisdiction
EP
Classification
—
Expires
2012-11-21
Drug substance claim
No
Drug product claim
No
Assignee
Universiteit Maastricht
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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