EP2485730A1 — Topical formulation comprising etoricoxib and a zwitterionic surfactant

USPTO Abstract

The present invention provides topical pharmaceutical compositions, methods for preparation, and methods of treatment comprising a selective COX-2 inhibitor and useful for the treatment of pain, particularly pain associated with osteoarthritis. The compositions can provide good selective COX-2 inhibitor permeability and bioavailability at the target site. In certain preferred embodiments, the invention provides a pharmaceutical composition comprising etoricoxib, a zwitterionic surfactant or charged derivative thereof, an alpha-hydroxy acid, at least one molecular penetration enhancer, at least one lower alcohol, and water.