EP2457914A1 — Compounds comprising short aminoalcohol chains and metal complexes for medical imaging

USPTO Abstract

The present invention relates to a compound of formula (IIa) of following general formulae: in which: R1, R2 and R3 represent, independently of one another, -COOH, -P(O)(OH) 2 or -R 6 -P(O)-OH in which R 6 represents an H atom or a C 1 -C 3 alkyl group; X 1 , X 2 and X 3 represent, independently of one another, L-Y in which L represents a C 1 -C 3 alkyl group, Y represents -NR7-CO-R8, in which R7 represents H or a C 1 -C 6 alkyl group or a C 1 -C 6 hydroxyalkyl group, and R8 represents a C 1 -C 6 alkyl or C 1 -C 6 hydroxyalkyl group, provided that at least R7 or R8 represents a C 1 -C 6 hydroxyalkyl group; D represents CH or N; E represents CH or N; F 1 represents CH or N; K 1 to K 12 each independently represent H, -(CH 2 ) j -CH 3 or -(CH 2 ) i -OH, in which j = 0 to 3 and i = 1 to 3, or K 3 or K 4 with K 5 or K 6 , and/or K 7 or K 8 with K 9 or K 10 , form a ring having 3 to 6 carbon atoms; or an isomer, an enantiomer or a diastereoisomer of these or their mixtures.