EP2455374A1 — Process for the Preparation of Compounds useful as inhibitors of SGLT

USPTO Abstract

The present invention is directed to a novel process for the preparation of compounds of Formula I having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney. wherein Ring A and Ring B are one of the following: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; or (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, or an optionally substituted unsaturated fused heterobicyclic ring wherein Y is linked to the heterocyclic ring of the fused heterobicyclic ring; or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, wherein the sugar moiety X-(sugar) and the moiety -Y-(Ring B) are both on the same heterocyclic ring of the fused heterobicyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; X is a carbon atom; Y is -(CH 2 ) n -; wherein n is 1 or 2; provided that in Ring A, X is part of an unsaturated bond; or a pharmaceutically acceptable salt or solvate thereof.