EP2435051A1 — Oxazolidinone containing dimer compounds, compositions and methods to make and use

USPTO Abstract

Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula (IV) wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR 1 or NR 1 R 2 ; wherein R 1 and R 2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.